Size :50ul
Clone Number:5G11
Aliases:TERF1-interacting nuclear factor 2 (TRF1-interacting nuclear protein 2), TINF2, TIN2
Product Type:Recombinant Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:Q9BSI4
Immunogen:A synthesized peptide derived from human Tin2
Raised in:
Species Reactivity:Human, Mouse, Rat
Tested Applications:ELISA, WB; Recommended dilution: WB:1:500-1:5000
Background:Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.
Clonality:Monoclonal
Isotype:Rabbit IgG
Purification Method:Affinity-chromatography
Conjugate:Non-conjugated
Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:TINF2
Research Areas:Epigenetics and Nuclear Signaling