Size :50ug
Clone Number:
Aliases:CRCS3 antibody; FLJ16482 antibody; hSMAD 7 antibody; hSMAD7 antibody; MAD (mothers against decapentaplegic Drosophila) homolog 7 antibody; MAD antibody; Mad homolog 7 antibody; MAD homolog 8 antibody; MAD mothers against decapentaplegic homolog 7 antibody; MADH 7 antibody; MADH 8 antibody; MADH6 antibody; MADH7 antibody; MADH8 antibody; Mothers Against Decapentaplegic Drosophila Homolog of 6 antibody; Mothers Against Decapentaplegic Drosophila Homolog of 7 antibody; Mothers against decapentaplegic homolog 7 antibody; Mothers against decapentaplegic homolog 8 antibody; Mothers against DPP homolog 7 antibody; Mothers against DPP homolog 8 antibody; SMA- AND MAD-RELATED PROTEIN 7 antibody; SMAD 7 antibody; SMAD antibody; SMAD family member 7 antibody; SMAD, mothers against DPP homolog 7 (Drosophila) antibody; SMAD, mothers against DPP homolog 7 antibody; SMAD6 antibody; Smad7 antibody; SMAD7_HUMAN antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:O15105
Immunogen:Recombinant Human Mothers against decapentaplegic homolog 7 protein (36-247AA)
Raised in:Rabbit
Species Reactivity:Human
Tested Applications:ELISA
Background:Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Clonality:Polyclonal
Isotype:IgG
Purification Method:>95%, Protein G purified
Conjugate:Biotin
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:SMAD7
Research Areas:Epigenetics and Nuclear Signaling; Signal transduction