Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Immunology
Uniprot NO.:P05113
Uniprot Entry Name:IL5_HUMAN
Gene Names:IL5
Species:Homo sapiens (Human)
Source:E.Coli
Expression Region:20-134aa
Sequence:M+IPTEIPTSA LVKETLALLS THRTLLIANE TLRIPVPVHK NHQLCTEEIF QGIGTLESQT VQGGTVERLF KNLSLIKKYI DGQKKKCGEE RRRVNQFLDY LQEFLGVMNT EWIIES
Protein Description:Full Length of Mature Protein
Tag Info:Tag-Free
Mol. Weight:13.3 kDa
Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 0.1 ng/ml, corresponding to a specific activity of ? 1.0 × 107 IU/mg.
Purity:>98% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a a 0.2 µm filtered 20mM PB, pH 7.5, 3 % trehalose, 0.1 % Tween-80
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:IL-5, Eosinophil differentiation factor, T-cell replacing factor, TRF,
Relevance:Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.
PubMed ID:3024129; 2824500; 3498940; 2823259; 15489334; 2361960; 2037074; 8483502; 22153509
Function:Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.
Involvement in disease:
Subcellular Location:Secreted
Protein Families:IL-5 family
Tissue Specificity:
Paythway:Jak-STATsignalingpathway
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:6016
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=2247
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:3567
STRING Database Link:https://string-db.org/network/9606.ENSP00000231454
OMIM Database Link:https://www.omim.org/entry/147850147850147850