Size :50ul
Clone Number:4A6
Aliases:Mixed lineage kinase domain-like protein, hMLKL, MLKL
Product Type:Recombinant Antibody
Immunogen Species:Human
UniProt ID:Q8NB16
Immunogen:A synthesized peptide derived from human Phospho-MLKL (S358)
Raised in:
Species Reactivity:Human
Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:50-1:200
Background:Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
Clonality:Monoclonal
Isotype:Rabbit IgG
Purification Method:Affinity-chromatography
Conjugate:Non-conjugated
Buffer:Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:MLKL
Research Areas:Signal Transduction