DKK1 Antibody - Cat. #: CSB-RA576260A0HU

DKK1 Antibody - Cat. #: CSB-RA576260A0HU

CSB-RA576260A0HU
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Size :50ul

Clone Number:1D12

Aliases:Dickkopf-related protein 1 (Dickkopf-1) (Dkk-1) (hDkk-1) (SK), DKK1

Product Type:Recombinant Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O94907

Immunogen:A synthesized peptide derived from human DKK1

Raised in:

Species Reactivity:Human

Tested Applications:ELISA, WB; Recommended dilution: WB:1:500-1:5000

Background:Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).

Clonality:Monoclonal

Isotype:Rabbit IgG

Purification Method:Affinity-chromatography

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:DKK1

Research Areas:Cardiovascular; Developmental biology; Immunology; Stem cells

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