Size :50ul
Clone Number:
Aliases:BAG 3 antibody; BAG family molecular chaperone regulator 3 antibody; BAG-3 antibody; Bag3 antibody; BAG3_HUMAN antibody; Bcl 2 binding protein antibody; Bcl-2-associated athanogene 3 antibody; Bcl-2-binding protein Bis antibody; BCL2 associated athanogene 3 antibody; BCL2 binding athanogene 3 antibody; BIS antibody; CAIR 1 antibody; Docking protein CAIR 1 antibody; Docking protein CAIR-1 antibody; MFM6 antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:O95817
Immunogen:Fusion protein of Human BAG3
Raised in:Rabbit
Species Reactivity:Human, Mouse
Tested Applications:ELISA, WB, IHC; ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100
Background:BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
Clonality:Polyclonal
Isotype:IgG
Purification Method:Antigen affinity purification
Conjugate:Non-conjugated
Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:BAG3
Research Areas:Cancer;Cell biology;Metabolism