Size :50ul
Clone Number:2E1
Aliases:Transcription factor SOX-2, SOX2
Product Type:Recombinant Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:P48431
Immunogen:A synthesized peptide derived from human SOX2
Raised in:
Species Reactivity:Human, Mouse, Rat
Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200
Background:Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
Clonality:Monoclonal
Isotype:Rabbit IgG
Purification Method:Affinity-chromatography
Conjugate:Non-conjugated
Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:SOX2
Research Areas:Epigenetics and Nuclear Signaling; Neuroscience; Developmental biology; Signal transduction; Stem cells