Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Immunology
Uniprot NO.:P10855
Uniprot Entry Name:CCL3_MOUSE
Gene Names:Ccl3,Mip1a,Scya3
Species:Mus musculus (Mouse)
Source:E.Coli
Expression Region:24-92aa
Sequence:APYGADTPTA CCFSYSRKIP RQFIVDYFET SSLCSQPGVI FLTKRNRQIC ADSKETWVQE YITDLELNA
Protein Description:Full Length of Mature Protein
Tag Info:Tag-Free
Mol. Weight:7.9 kDa
Biological_Activity:Fully biologically active when compared to standard. The biological activity determined by a chemoattract bioassay using murine splenocytes is in a concentration range of 10-100 ng/ml.
Purity:>98% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 ?m filtered concentrated solution in 30 % Acetonitrile and 0.1 % TFA
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:Heparin-binding chemotaxis protein, Macrophage inflammatory protein 1-alpha, MIP-1-alpha, SIS-alpha, Small-inducible cytokine A3
Relevance:Monokine with inflammatory, pyrogenic and chemokinetic properties. Has a potent chemotactic activity for eosinophils. Binding to a high-affinity receptor activates calcium release in neutrophils.
PubMed ID:3290382; 2521353; 2216738; 2784565; 2033269; 10438970; 3279154
Function:Monokine with inflammatory, pyrogenic and chemokinetic properties. Has a potent chemotactic activity for eosinophils. Binding to a high-affinity receptor activates calcium release in neutrophils.
Involvement in disease:
Subcellular Location:Secreted
Protein Families:Intercrine beta (chemokine CC) family
Tissue Specificity:Expressed in lung, spleen, and pancreas.
Paythway:
HGNC Database Link:
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=1282
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?mmu:20302
STRING Database Link:https://string-db.org/network/10090.ENSMUSP00000001008
OMIM Database Link: