Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Immunology
Uniprot NO.:Q6UXB2
Uniprot Entry Name:VCC1_HUMAN
Gene Names:CXCL17,VCC1,UNQ473/PRO842
Species:Homo sapiens (Human)
Source:E.Coli
Expression Region:22-119aa
Sequence:SSLNPGVARG HRDRGQASRR WLQEGGQECE CKDWFLRAPR RKFMTVSGLP KKQCPCDHFK GNVKKTRHQR HHRKPNKHSR ACQQFLKQCQ LRSFALPL
Protein Description:Full Length of Mature Protein
Tag Info:Tag-Free
Mol. Weight:11.5 kDa
Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by its ability to induce VEGF expression using murine endothelial cells is less than 5.0 ?g/ml, corresponding to a specific activity of ? 200 IU/mg.
Purity:>96% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:C-X-C motif chemokine 17, DMC
Relevance:Plays a role in angiogenesis and possibly in the development of tumors. May be a housekeeping chemokine regulating recruitment of nonactivated blood monocytes and immature dendritic cells into tissues. May play a role in the innate defense against infections. {ECO:0000269|PubMed:16455961, ECO:0000269|PubMed:16989774, ECO:0000269|PubMed:17307946}.
PubMed ID:16989774; 12975309; 14702039; 15489334; 15340161; 16455961; 17307946
Function:Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells
Involvement in disease:
Subcellular Location:Secreted
Protein Families:Intercrine alpha (chemokine CxC) family
Tissue Specificity:Detected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal and asthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up-regulation.
Paythway:
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:19232
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=445586
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:284340
STRING Database Link:https://string-db.org/network/9606.ENSP00000472467
OMIM Database Link:https://www.omim.org/entry/611387611387611387