Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Immunology
Uniprot NO.:Q96PD4
Uniprot Entry Name:IL17F_HUMAN
Gene Names:IL17F
Species:Homo sapiens (Human)
Source:E.Coli
Expression Region:31-163aa
Sequence:M+RKIPKVGHT FFQKPESCPP VPGGSMKLDI GIINENQRVS MSRNIESRST SPWNYTVTWD PNRYPSEVVQ AQCRNLGCIN AQGKEDISMN SVPIQQETLV VRRKHQGCSV SFQLEKVLVT VGCTCVTPVI HHVQ
Protein Description:Full Length of Mature Protein
Tag Info:Tag-Free
Mol. Weight:15 kDa
Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by inducing IL-6 secretion of murine NIH/3T3 cells is less than 20 ng/ml, corresponding to a specific activity of ? 5.0 × 104 IU/mg.
Purity:>95% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:IL-17F,
Relevance:Stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis.
PubMed ID:11591732; 14574404; 15489334; 11591768; 15340161; 11574464; 19838198; 21350122
Function:Ligand for IL17RA and IL17RC
Involvement in disease:Candidiasis, familial, 6 (CANDF6)
Subcellular Location:Secreted
Protein Families:IL-17 family
Tissue Specificity:Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.
Paythway:IL-17signalingpathway
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:16404
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=272295
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:112744
STRING Database Link:https://string-db.org/network/9606.ENSP00000337432
OMIM Database Link:https://www.omim.org/entry/606496606496606496