Size :50ul
Clone Number:4B10
Aliases:NPC1-like intracellular cholesterol transporter 1 (Niemann-Pick C1-like protein 1), NPC1L1
Product Type:Recombinant Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:Q9UHC9
Immunogen:A synthesized peptide derived from human NPC1L1
Raised in:
Species Reactivity:Human
Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:50-1:200
Background:Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation.
Clonality:Monoclonal
Isotype:Rabbit IgG
Purification Method:Affinity-chromatography
Conjugate:Non-conjugated
Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:NPC1L1
Research Areas:Neuroscience; Cancer; Cardiovascular; Metabolism; Signal transduction