Loxl2 Antibody, FITC conjugated - Cat. #: CSB-PA013041LC01MO

Loxl2 Antibody, FITC conjugated - Cat. #: CSB-PA013041LC01MO

CSB-PA013041LC01MO
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Size :50ug

Clone Number:

Aliases:Loxl2Lysyl oxidase homolog 2 antibody; EC 1.4.3.13 antibody; Lysyl oxidase-like protein 2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Mus musculus (Mouse)

UniProt ID:P58022

Immunogen:Recombinant Mouse Lysyl oxidase homolog 2 protein (26-776AA)

Raised in:Rabbit

Species Reactivity:Mouse

Tested Applications:

Background:Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated Lys-4 of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3 By similarity. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:Loxl2

Research Areas:Cancer; Signal transduction

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