Size :100ul
Clone Number:
Aliases:Abundant SRC homology; Adapter protein GRB2; ASH; Ash protein; EGFRBP GRB2; Epidermal growth factor receptor binding protein; Epidermal growth factor receptor binding protein GRB2; GRB 2; GRB2 adapter protein; Grb2; GRB2_HUMAN; Grb3 3;
Product Type:Monoclonal Antibody
Immunogen Species:Human
UniProt ID:P62993
Immunogen:Purified recombinant human GRB2 protein fragments expressed in E.coli.
Raised in:Mouse
Species Reactivity:Human,Rat,Mouse,Monkey
Tested Applications:ELISA,WB;Recommended dilution:WB:1:500-1:5000
Background:Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
Clonality:Monoclonal
Isotype:IgG1
Purification Method:Affinity purified
Conjugate:Non-conjugated
Buffer:Ascites
Form:liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:GRB2
Research Areas:Cancer;Signal transduction