Size :50ug
Clone Number:
Aliases:exo1 antibody; EXO1_HUMAN antibody; ExoI antibody; Exonuclease 1 antibody; Exonuclease I antibody; Exonuclease1 antibody; HEX1 antibody; hExo I antibody; hExo1 antibody; hExoI antibody; Rad2 nuclease family member homolog of S. cerevisiae exonuclease 1 antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:Q9UQ84
Immunogen:Recombinant Human Exonuclease 1 protein (301-600AA)
Raised in:Rabbit
Species Reactivity:Human
Tested Applications:ELISA
Background:5\'->3\' double-stranded DNA exonuclease which may also possess a cryptic 3\'->5\' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5\' or 3\' to the mismatch. Also exhibits endonuclease activity against 5\'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5\'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.
Clonality:Polyclonal
Isotype:IgG
Purification Method:>95%, Protein G purified
Conjugate:Biotin
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:EXO1
Research Areas:Epigenetics and Nuclear Signaling