Size :50ul
Clone Number:
Aliases:eed antibody; EED protein antibody; EED; mouse; homolog of antibody; EED_HUMAN antibody; Embryonic ectoderm development antibody; Embryonic ectoderm development isoform a antibody; Embryonic ECTODERM development protein homolog antibody; Embryonic ectoderm development protein; mouse; homolog of antibody; hEED antibody; OTTHUMP00000235483 antibody; OTTHUMP00000235484 antibody; OTTHUMP00000235485 antibody; Polycomb protein eed antibody; WAIT 1 antibody; WAIT-1 antibody; WAIT1 antibody; WD protein associating with integrin cytoplasmic tails 1 antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:O75530
Immunogen:Recombinant Human Polycomb protein EED protein (1-300AA)
Raised in:Rabbit
Species Reactivity:Human
Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200
Background:Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates \\\'Lys-9\\\' and \\\'Lys-27\\\' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes \\\'Lys-26\\\' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 \\\'Lys-27\\\', whereas H3 \\\'Lys-27\\\' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
Clonality:Polyclonal
Isotype:IgG
Purification Method:Antigen Affinity Purified
Conjugate:Non-conjugated
Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:EED
Research Areas:Epigenetics and Nuclear Signaling