Size :50ug
Clone Number:1A11C11
Aliases:Chromogranin-A,CgA,Pituitary secretory protein I,SP-I,Vasostatin II,CHGA
Product Type:Monoclonal Antibody
Immunogen Species:Human
UniProt ID:P10645
Immunogen:Recombinant CHGA Protein
Raised in:Mouse
Species Reactivity:Human
Tested Applications:ELISA,WB,IHC;Recommended dilution:WB:1:500-1:5000,IHC:1:50-1:500
Background:Chromogranin A is a member of the granin family of neuroendocrine secretory proteins. It is located in secretory vesicles of neurons and endocrine cells. Chromogranin A is the precursor to several functional peptides including vasostatin, pancreastatin, catestatin and parastatin. These peptides negatively modulate the neuroendocrine function of the releasing cell (autocrine) or nearby cells (paracrine). CgA is one of the most used tumor markers in NET's (neuroendocrine tumors) , and elevated CgA concentrations have been demonstrated in serum or plasma of patients with different types of these tumors. However, CgA is not a tumor-specific antigen for NETs, and an abnormal concentration has been described in some non-malignant diseases such as renal failure, heart failure, proton pump inhibition, gastritis, hypertension, or patients with liver diseases.
Clonality:Monoclonal
Isotype:IgG1
Purification Method:>95%,Protein G purified
Conjugate:Non-conjugated
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form:liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:CHGA
Research Areas:Neuroscience?Cancer;Tags & Cell Markers;Signal transduction