Size :50ul
Clone Number:3C3
Aliases:Cell division control protein 42 homolog (G25K GTP-binding protein), CDC42
Product Type:Recombinant Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:P60953
Immunogen:A synthesized peptide derived from human CDC42
Raised in:
Species Reactivity:Human, Mouse
Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200
Background:Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity).
Clonality:Monoclonal
Isotype:Rabbit IgG
Purification Method:Affinity-chromatography
Conjugate:Non-conjugated
Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:CDC42
Research Areas:Epigenetics and Nuclear Signaling; Cancer; Cell biology; Signal transduction