Size :50ul
Clone Number:4D10C7
Aliases:Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146), MCAM, MUC18
Product Type:Monoclonal Antibody
Immunogen Species:Human
UniProt ID:P43121
Immunogen:Recombinant Human Cell surface glycoprotein MUC18 protein (50-646AA)
Raised in:Mouse
Species Reactivity:Human
Tested Applications:ELISA, WB, IF, FC; Recommended dilution: WB:1:500-1:2000, IF:1:50-1:200
Background:Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
Clonality:Monoclonal
Isotype:IgG2a
Purification Method:>95%, Protein G purified
Conjugate:Non-conjugated
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:CD146
Research Areas:Immunology