Size :50ug
Clone Number:3D2E5
Aliases:Monocyte chemoattractant protein 1,Monocyte chemotactic and activating factor,Monocyte chemotactic protein 1,Monocyte secretory protein JE,Small-inducible cytokine A2,CCL2,MCP1, SCYA2
Product Type:Monoclonal Antibody
Immunogen Species:Human
UniProt ID:P13500
Immunogen:Recombinant Human C-C motif chemokine 2
Raised in:Mouse
Species Reactivity:Human
Tested Applications:ELISA,IHC;Recommended dilution:IHC:1:50-1:500
Background:Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. [1] "Cloning and sequencing of the cDNA for human monocyte chemotactic and activating factor (MCAF)."Furutani Y., Nomura H., Notake M., Oyamada Y., Fukui T., Yamada M., Larsen C.G., Oppenheim J.J., Matsushima K.Biochem. Biophys. Res. Commun. 159:249-255(1989) [2] "The human homolog of the JE gene encodes a monocyte secretory protein."Rollins B.J., Stier P., Ernst T., Wong G.G.Mol. Cell. Biol. 9:4687-4695(1989) [3] "Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE."Yoshimura T., Yuhki N., Moore S.K., Appella E., Lerman M.I., Leonard E.J.FEBS Lett. 244:487-493(1989)
Clonality:Monoclonal
Isotype:IgG2b
Purification Method:>95%,Protein G purified
Conjugate:Non-conjugated
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form:liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:CCL2
Research Areas:Cancer?Cardiovascular;Immunology?Metabolism