Size :100ul
Clone Number:
Aliases:3010002G07Rik; BRAP2; BRCA1 associated protein; EC 6.3.2.; Galectin 2 binding protein; IMP; Impedes mitogenic signal propagation; Renal carcinoma antigen NY REN 63; RING finger protein 52; RNF52; zgc:92894.
Product Type:Monoclonal Antibody
Immunogen Species:Human
UniProt ID:Q7Z569
Immunogen:Purified recombinant human BRAP protein fragments expressed in E.coli.
Raised in:Mouse
Species Reactivity:Human
Tested Applications:ELISA,WB;Recommended dilution:WB:1:500-1:5000
Background:Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
Clonality:Monoclonal
Isotype:IgG1
Purification Method:Affinity purified
Conjugate:Non-conjugated
Buffer:Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:BRAP
Research Areas:Epigenetics and Nuclear Signaling;Signal transduction