APC Antibody - Cat. #: CSB-RA951649A0HU

CSB-RA951649A0HU

Size :50ul

Clone Number:5F2

Aliases:Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5), APC, DP2.5

Product Type:Recombinant Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P25054

Immunogen:A synthesized peptide derived from human APC

Raised in:

Species Reactivity:Human, Rat

Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200

Background:Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.

Clonality:Monoclonal

Isotype:Rabbit IgG

Purification Method:Affinity-chromatography

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:APC

Research Areas:Epigenetics and Nuclear Signaling; Neuroscience; Cancer; Cardiovascular; Cell biology; Stem cells