Size :50ul
Clone Number:11H10
Aliases:Multidrug resistance protein 1 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 1) (P-glycoprotein 1) (CD antigen CD243), ABCB1, MDR1 PGY1
Product Type:Recombinant Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:P08183
Immunogen:A synthesized peptide derived from human ABCB1
Raised in:
Species Reactivity:Human
Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:50-1:200, IF:1:50-1:200
Background:Translocates drugs and phospholipids across the membrane (PubMed:8898203, PubMed:2897240, PubMed:9038218). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:9038218). {ECO:0000269|PubMed:2897240, ECO:0000269|PubMed:8898203, ECO:0000269|PubMed:9038218}.
Clonality:Monoclonal
Isotype:Rabbit IgG
Purification Method:Affinity-chromatography
Conjugate:Non-conjugated
Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:ABCB1
Research Areas:Cancer; Metabolism; Signal transduction; Stem cells