Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Immunology
Uniprot NO.:Q9UHF5
Uniprot Entry Name:IL17B_HUMAN
Gene Names:IL17B,IL20,NIRF,ZCYTO7,UNQ516/PRO1031
Species:Homo sapiens (Human)
Source:E.Coli
Expression Region:21-180aa
Sequence:M+QPRSPKSKR KGQGRPGPLA PGPHQVPLDL VSRMKPYARM EEYERNIEEM VAQLRNSSEL AQRKCEVNLQ LWMSNKRSLS PWGYSINHDP SRIPVDLPEA RCLCLGCVNP FTMQEDRSMV SVPVFSQVPV RRRLCPPPPR TGPCRQRAVM ETIAVGCTCI F
Protein Description:Full Length of Mature Protein
Tag Info:Tag-Free
Mol. Weight:18.3 kDa
Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by inducing IL-8 secretion of human HepG2 cells is less than 1.0 ?g/ml, corresponding to a specific activity of ? 1000 IU/mg.
Purity:>95% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4, with 0.1 % Tween-20 and 3 % Trehalose
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:IL-17B, Interleukin-20, IL-20, Neuronal interleukin-17-related factor,
Relevance:Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.
PubMed ID:10749887; 10639155; 12975309; 15489334
Function:Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.
Involvement in disease:
Subcellular Location:Secreted
Protein Families:IL-17 family
Tissue Specificity:Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.
Paythway:IL-17signalingpathway
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:5982
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=156979
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:27190
STRING Database Link:https://string-db.org/network/9606.ENSP00000261796
OMIM Database Link:https://www.omim.org/entry/604627604627604627