Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Neuroscience
Uniprot NO.:P26441
Uniprot Entry Name:CNTF_HUMAN
Gene Names:CNTF
Species:Homo sapiens (Human)
Source:E.Coli
Expression Region:1-200aa
Sequence:MAFTEHSPLT PHRRDLCSRS IWLARKIRSD LTALTESYVK HQGLNKNINL DSADGMPVAS TDQWSELTEA ERLQENLQAY RTFHVLLARL LEDQQVHFTP TEGDFHQAIH TLLLQVAAFA YQIEELMILL EYKIPRNEAD GMPINVGDGG LFEKKLWGLK VLQELSQWTV RSIHDLRFIS SHQTGIPARG SHYIANNKKM
Protein Description:Full Length
Tag Info:Tag-Free
Mol. Weight:22.9 kDa
Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 150 ng/ml, corresponding to a specific activity of ? 6.7 × 103 IU/mg.
Purity:>97% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:CNTF,
Relevance:CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
PubMed ID:1861138; 1915374; 1840538; 1883844; 8075647; 14702039; 15489334; 7796798; 10391209
Function:CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
Involvement in disease:
Subcellular Location:Cytoplasm
Protein Families:CNTF family
Tissue Specificity:Nervous system.
Paythway:Jak-STATsignalingpathway
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:2169
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=524920
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:1270
STRING Database Link:https://string-db.org/network/9606.ENSP00000355370
OMIM Database Link:https://www.omim.org/entry/118945118945118945