Size :50ug
Clone Number:2C12F3
Aliases:MutS Homolog 6,GTBP,HSAP2,DNA Mismatch Repair Protein Msh6,G/T Mismatch-Binding Protein
Product Type:Monoclonal Antibody
Immunogen Species:Human
UniProt ID:P52701
Immunogen:Recombinant Human MSH6 Protein
Raised in:Mouse
Species Reactivity:Human
Tested Applications:ELISA,IHC;Recommended dilution:IHC:1:50-1:500
Background:This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa,called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have beendescribed.
Clonality:Monoclonal
Isotype:IgG
Purification Method:>95%,Protein G purified
Conjugate:Non-conjugated
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form:liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:MSH6
Research Areas:Epigenetics and Nuclear Signaling