Size :100ul
Clone Number:
Aliases:ABC transporter antibody; ABC15 antibody; ABCG 2 antibody; ABCG2 antibody; ABCG2_HUMAN antibody; ABCP antibody; ATP binding cassette sub family G (WHITE) member 2 antibody; ATP binding cassette transporter G2 antibody; ATP-binding cassette sub-family G member 2 antibody; BCRP antibody; BCRP1 antibody; BMDP antibody; Breast cancer resistance protein antibody; CD338 antibody; CDw338 antibody; CDw338 antigen antibody; EST157481 antibody; GOUT1 antibody; MGC102821 antibody; Mitoxantrone resistance associated protein antibody; Mitoxantrone resistance-associated protein antibody; MRX antibody; Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2 antibody; MXR antibody; MXR1 antibody; Placenta specific ATP binding cassette transporter antibody; Placenta specific MDR protein antibody; Placenta-specific ATP-binding cassette transporter antibody; UAQTL1 antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:Q9UNQ0
Immunogen:Peptide sequence around aa.160~164( R-I-N-R-V) derived from Human ABCG2(CD338).
Raised in:Rabbit
Species Reactivity:Human
Tested Applications:ELISA, WB; WB:1:500-1:1000
Background:
Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.
Henriksen U., Gether U., Litman T.J. Cell Sci. 118:1417-1426(2005) Wakabayashi K., Nakagawa H., Tamura A., Koshiba S., Hoshijima K., Komada M., Ishikawa T. J. Biol. Chem. 282:27841-27846(2007)
Clonality:Polyclonal
Isotype:IgG
Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Conjugate:Non-conjugated
Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form:liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:ABCG2
Research Areas:Cancer;Tags & Cell Markers;Metabolism;Signal transduction?Stem cells