Size :50ul
Clone Number:
Aliases:ABC39 antibody; Abcd2 antibody; ABCD2_HUMAN antibody; Adrenoleukodystrophy-like 1 antibody; Adrenoleukodystrophy-related protein antibody; ALDL1 antibody; ALDR antibody; ALDRP antibody; ATP-binding cassette sub-family D member 2 antibody; hALDR antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:Q9UBJ2
Immunogen:Synthetic peptide of Human ABCD2
Raised in:Rabbit
Species Reactivity:Human, Mouse, Rat
Tested Applications:ELISA, IHC; ELISA:1:2000-1:5000, IHC:1:25-1:100
Background:The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis.
Clonality:Polyclonal
Isotype:IgG
Purification Method:Antigen affinity purification
Conjugate:Non-conjugated
Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:ABCD2
Research Areas:Cancer?Cardiovascular;Tags & Cell Markers;Metabolism;Signal transduction