Size :50ul
Clone Number:
Aliases:ABC 33 antibody; ABC33 antibody; ABCC 5 antibody; Abcc5 antibody; ATP binding cassette sub family C (CFTR/MRP) member 5 antibody; ATP binding cassette sub family C member 5 antibody; ATP-binding cassette sub-family C member 5 antibody; Canalicular multispecific organic anion transporter C antibody; DKFZp686C1782 antibody; EST277145 antibody; MOAT C antibody; MOAT-C antibody; MOATC antibody; MRP 5 antibody; MRP5_HUMAN antibody; Multi specific organic anion tranporter C antibody; Multi-specific organic anion transporter C antibody; Multidrug resistance associated protein 5 antibody; Multidrug resistance-associated protein 5 antibody; pABC 11 antibody; pABC11 antibody; SMRP antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:O15440
Immunogen:Synthetic peptide of Human ABCC5
Raised in:Rabbit
Species Reactivity:Human, Mouse, Rat
Tested Applications:ELISA, WB, IHC; ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:50-1:200
Background:The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.
Clonality:Polyclonal
Isotype:IgG
Purification Method:Antigen affinity purification
Conjugate:Non-conjugated
Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:ABCC5
Research Areas:Cancer;Metabolism;Signal transduction