Size :100ul
Clone Number:
Aliases:DKFZp781P0919 antibody; DNA repair protein XRCC2 antibody; X ray repair complementing defective repair in Chinese hamster cells 2 antibody; X ray repair cross complementing protein 2 antibody; X-ray repair cross-complementing protein 2 antibody; Xrcc2 antibody; XRCC2_HUMAN antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:O43543
Immunogen:Synthesized peptide derived from internal of Human XRCC2.
Raised in:Rabbit
Species Reactivity:Human
Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100
Background:Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.
JP Scott, Blood, Oct 1981; 58: 665 - 669.
G Chevalier, Am. J. Pathol., Jun 1998; 152: 1563.
R Williams, J. Biol. Chem., Aug 1993; 268: 18213 - 18217.
Michael R. Ladomery, J. Biol. Chem., Dec 1999; 274: 36520.
Clonality:Polyclonal
Isotype:IgG
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Conjugate:Non-conjugated
Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form:liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:XRCC2
Research Areas:Epigenetics and Nuclear Signaling