Size:100ug. Other sizes are also available. For further information, please contact us.
Research Areas:Immunology
Uniprot ID:P33681
Gene Names:CD80
Organism:Homo sapiens (Human)
AA Sequence:VIHVTKEVKEVATLSCGHNVSVEELAQTRIYWQKEKKMVLTMMSGDMNIWPEYKNRTIFDITNNLSIVILALRPSDEGTYECVVLKYEKDAFKREHLAEVTLSVKADFPTPSISDFEIPTSNIRRIICSTSGGFPEPHLSWLENGEELNAINTTVSQDPETELYAVSSKLDFNMTTNHSFMCLIKYGHLRVNQTFNWNTTKQEHFPDN
Expression Region:35-242aa
Sequence Info:Partial
Source:Mammalian cell
Tag Info:C-terminal hFc-Myc-tagged
MW:54.0 kDa
Alternative Name(s):Activation B7-1 antigen (BB1) (CTLA-4 counter-receptor B7.1) (B7) (CD80) (CD28LG) (CD28LG1) (LAB7)
Relevance:Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.Acts as a receptor for adenovirus subgroup B.
Reference:"Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors." Short J.J., Vasu C., Holterman M.J., Curiel D.T., Pereboev A. Virus Res. 122:144-153(2006)
Purity:Greater than 85% as determined by SDS-PAGE.
Form:Liquid or Lyophilized powder
Buffer:If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Storage:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Function:Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
Involvement in disease:
Subcellular Location:Membrane, Single-pass type I membrane protein
Protein Families:
Tissue Specificity:Expressed on activated B-cells, macrophages and dendritic cells.
Paythway:Toll-likereceptorsignalingpathway
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:1700
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=838
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:941
STRING Database Link:https://string-db.org/network/9606.ENSP00000264246
OMIM Database Link:https://www.omim.org/entry/112203112203112203
Lead Time Guidance:18-28 business days