Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Immunology
Uniprot NO.:Q9GZX6
Uniprot Entry Name:IL22_HUMAN
Gene Names:IL22,ILTIF,ZCYTO18,UNQ3099/PRO10096
Species:Homo sapiens (Human)
Source:E.Coli
Expression Region:34-179aa
Sequence:M+APISSHCRL DKSNFQQPYI TNRTFMLAKE ASLADNNTDV RLIGEKLFHG VSMSERCYLM KQVLNFTLEE VLFPQSDRFQ PYMQEVVPFL ARLSNRLSTC HIEGDDLHIQ RNVQKLKDTV KKLGESGEIK AIGELDLLFM SLRNACI
Protein Description:Full Length of Mature Protein
Tag Info:Tag-Free
Mol. Weight:16.9 kDa
Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by inducing IL-10 secretion of human COLO 205 cells is less than 0.3 ng/ml, corresponding to a specific activity of ? 3.3 × 106 IU/mg.
Purity:>97% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 5.0
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:IL-22, IL-10-related T-cell-derived-inducible factor, IL-TIF
Relevance:Cytokine that contributes to the inflammatory response in vivo.
PubMed ID:10954742; 11197690; 10875937; 12975309; 15489334; 15340161; 11856845; 15983417; 18599299
Function:Cytokine that contributes to the inflammatory response in vivo.
Involvement in disease:
Subcellular Location:Secreted
Protein Families:IL-10 family
Tissue Specificity:
Paythway:Jak-STATsignalingpathway
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:14900
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=287369
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:50616
STRING Database Link:https://string-db.org/network/9606.ENSP00000329384
OMIM Database Link:https://www.omim.org/entry/605330605330605330