Size:500ug. Other sizes are also available. Please contact us.
Research Areas:Immunology
Uniprot NO.:P60568
Uniprot Entry Name:IL2_HUMAN
Gene Names:IL2
Species:Homo sapiens (Human)
Source:E.Coli
Expression Region:21-153aa
Sequence:APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT
Protein Description:Full Length of Mature Protein
Tag Info:Tag-Free
Mol. Weight:15.4 kDa
Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine CTLL-2 cells is less than 0.1 ng/ml, corresponding to a specific activity of ? 1.0 × 107 IU/mg.
Purity:>97% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 ?m filtered 20 mM PB, pH 3.5
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:IL-2, TCGF, Aldesleukin
Relevance:Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
PubMed ID:6312994; 6403867; 6306584; 6324170; 6330695; 6608729; 7722480; 8824916; 15489334; 3491296; 3264184; 6333684; 2793860; 3500515; 1631562; 1510960; 7529123; 16293754; 16477002
Function:Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Involvement in disease:A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
Subcellular Location:Secreted
Protein Families:IL-2 family
Tissue Specificity:
Paythway:Jak-STATsignalingpathway
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:6001
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=89679
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:3558
STRING Database Link:https://string-db.org/network/9606.ENSP00000226730
OMIM Database Link:https://www.omim.org/entry/147680147680147680