HDAC3 Antibody - Cat. #: CSB-RA906662A0HU

HDAC3 Antibody - Cat. #: CSB-RA906662A0HU

CSB-RA906662A0HU
Regular price
€402,95 EUR
Sale price
€402,95 EUR
Regular price
Sold out
Unit price
per 
Shipping calculated at checkout.

Size :50ul

Clone Number:4D4

Aliases:Histone deacetylase 3 (HD3) (EC 3.5.1.98) (RPD3-2) (SMAP45), HDAC3

Product Type:Recombinant Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O15379

Immunogen:A synthesized peptide derived from human HDAC3

Raised in:

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200

Background:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803).

Clonality:Monoclonal

Isotype:Rabbit IgG

Purification Method:Affinity-chromatography

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:HDAC3

Research Areas:Epigenetics and Nuclear Signaling; Cancer; Cardiovascular; Metabolism; Stem cells

Your list is ready to share